Barrett’s esophagus (BE) is the precursor to esophageal adenocarcinoma (EAC). Endoscopic eradication therapy (EET) can be effective in eradicating BE and related neoplasia and has greater risk of harms and resource use than surveillance endoscopy. This clinical practice guideline aims to inform clinicians and patients by providing evidence-based practice recommendations for the use of EET in BE and related neoplasia.

Present in all eukaryotic cells, the integrated stress response (ISR) is a highly coordinated signaling network that controls cellular behavior, metabolism and survival in response to diverse stresses. The ISR is initiated when any one of four stress sensing kinases (PERK, GCN2, PKR, HRI) becomes activated to phosphorylate the protein translation initiation factor eIF2α, shifting gene expression toward a comprehensive rewiring of cellular machinery to promote adaptation. While the ISR has been shown to play an important role in the homeostasis of multiple tissues, evidence suggests that it is particularly crucial for the development and ongoing health of the pancreas.

Specifications: Permanent – Full time
Salary: £27,500 per annum
Location: Remote/London (one day per week in London office)
Closing date:  31 May 2024

Cochrane is an international charity. For 30 years we have responded to the challenge of making vast amounts of research evidence useful for informing decisions about health. We do this by synthesising research findings and our work has been recognised as the international gold standard for high quality, trusted information.

Cochrane's strength is in its collaborative, global community. We have 110,000+ members and supporters around the world. Though we are spread out across the globe, our shared passion for health evidence unites us. Our Central Executive Team supports this work and is divided into five directorates: Evidence Production and Methods, Publishing and Technology, Development, Chief Executive Office and Finance and Corporate Services.

Cochrane is looking for a Communications and Events Assistant to support the team with a focus on media monitoring, social media and events.  This is a new role within the Communications team and will support colleagues across the team. This is a broad, entry-level role suitable for someone with an interest in science communication and events. The role will involve creating and posting content for internal and external communications, overseeing media monitoring and providing support for our flagship events.

Don’t have every single qualification? We know that some people are less likely to apply for a job unless they are a perfect match. At Cochrane, we’re not looking for “perfect matches.” We’re looking to welcome people to our diverse, inclusive, and passionate workplace. So, if you’re excited about this role but don’t have every single qualification, we encourage you to apply anyway. Whether it’s this role or another one, you may be just the right candidate.

Our organization is built on four core values:

Collaboration: Underpins everything we do, locally and globally.
Relevant: The right evidence at the right time in the right format.
Integrity: Independent and transparent.
Quality: Reviewing and improving what we do, maintaining rigour and trust.

You can expect:

• An opportunity to truly impact health globally.
• A flexible work environment
• A comprehensive onboarding experiences.
• An environment where people feel welcome, heard, and included, regardless of their differences.

Cochrane welcomes applications from a wide range of perspectives, experiences, locations, and backgrounds; diversity, equity and inclusion are key to our values.

How to apply

• For further information on the role and click “how to apply”.
• The deadline to receive your application is 31 May 2024.
• The supporting statement should indicate why you are applying for the post, and how far you meet the requirements, using specific examples.
• Read our Recruitment Privacy Statement

Friday, May 17, 2024 Category: Jobs

Friday, May 17, 2024

Long, long ago, medicine was regarded as 1 of the 3 learned professions, the others being the law and the church. “They were called the ‘learned professions’,” wrote Kenneth Hudson in The Jargon of the Professions (1978), “because entry to them was restricted to men who had followed a course in the humanities and were accepted as scholars“ (p. 22).1 When the first examination for the membership of the Royal College of Physicians of London was held in April 1859, the written papers included translation exercises in Latin, Greek, French, and German.

Gastrointestinal (GI) cancers are the leading cause of new cancer cases and cancer-related deaths worldwide. The treatment strategies for patients with GI tumors have focused on oncogenic molecular profiles associated with tumor cells. Recent evidence demonstrated that tumor cell functions are modulated by its microenvironment, compromising fibroblasts, ECMs, microbiome, immune cells, and the enteric nervous system. Along with the TME components, alterations in key metabolic pathways have emerged as a hallmark of tumor cells.

Title: Senior Managing Editor
Specifications: Permanent Fulltime
Salary: £52,000 per annum
Location: UK – Remote/Flexible
Closing date: 28 May 2024

Cochrane is an international charity. For 30 years we have responded to the challenge of making vast amounts of research evidence useful for informing decisions about health. We do this by synthesising research findings and our work has been recognised as the international gold standard for high quality, trusted information.

Cochrane's strength is in its collaborative, global community. We have 110,000+ members and supporters around the world. Though we are spread out across the globe, our shared passion for health evidence unites us. Our Central Executive Team supports this work and is divided into five directorates: Evidence Production and Methods, Publishing and Technology, Development,  Chief Executive Office and Finance and Corporate Services.

Reporting to the Executive Editor and working with members of the Editorial Production and Methods Directorate, the role holder will need to have good awareness of Cochrane guidance for different types of standard and complex systematic reviews (intervention, qualitative, diagnostic test accuracy, prognosis, rapid and overview), plan how they will need to be handled in their team, and work to ensure that deadlines are met. The role holder will also be required to ensure that pilots aimed at innovating the editorial process can be supported as needed.

Don’t have every single qualification? We know that some people are less likely to apply for a job unless they are a perfect match. At Cochrane, we’re not looking for “perfect matches.” We’re looking to welcome people to our diverse, inclusive, and passionate workplace. So, if you’re excited about this role but don’t have every single qualification, we encourage you to apply anyway. Whether it’s this role or another one, you may be just the right candidate.

Our organization is built on four core values: Collaboration: Underpins everything we do, locally and globally. Relevant: The right evidence at the right time in the right format. Integrity: Independent and transparent. Quality: Reviewing and improving what we do, maintaining rigour and trust.

You can expect:

• An opportunity to truly impact health globally
• A flexible work environment
• A comprehensive onboarding experiences
• An environment where people feel welcome, heard, and included, regardless of their differences

Cochrane welcomes applications from a wide range of perspectives, experiences, locations and backgrounds; diversity, equity and inclusion are key to our values.

How to apply

• For further information on the role and how to apply, please click here
• The deadline to receive your application is 28 May 2024
• The supporting statement should indicate why you are applying for the post, and how far you meet the requirements, using specific examples.
• Read our Recruitment Privacy Statement

Tuesday, May 14, 2024 Category: Jobs

I am an accidental, even reluctant, thanatologist. When The Way We Die Now1 was published in 2016, many people wondered how I—a gastroenterologist—came to write such a book. After all, this was territory usually occupied (and jealously guarded) by palliative care physicians. The book happened organically, almost by chance. For several years, I had been interested in the ethical aspects of percutaneous endoscopic gastrostomy (PEG) feeding. I am old enough to recall a time (the late 1980s and early 1990s) when gastroenterologists were expected (at least tacitly) to function as technicians, to carry out the instructions of their colleagues in neurology and gerontology, and not to involve themselves excessively in discussions on the appropriateness (or otherwise) of PEG insertion in individual patients.

Medicine owes as much to technology as it does to basic science. Endoscopy, for good and for bad, changed gastroenterology more than any other technology. In 1985, the eminent English gastroenterologist, Sir Christopher Booth, wrote a long essay1 for Gut, asking “What has technology done to gastroenterology?” This article was based on a lecture he had given in Berlin the year before. Booth (1924–2012) was one of the great beasts of British academic medicine during its glory years in the decades after World War II.